Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.

The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there are little data about LLT1 expression in human solid tumors. The objective of this paper is to investigate the relationship between LLT1 expression with the clinicopathologic features and its impact on the prognosis of head and neck cutaneous squamous cell carcinoma (cSCC). LLT1 expression was analyzed on paraffin-embedded tissue samples obtained from 100 patients with cSCC by immunohistochemistry. The estimator of Fine and Gray was used to estimate the cumulative incidence curves for relapse. Proportional Hazard models and Hazard ratios (HRs) were used for studying the risk of tumor relapse and mortality. LLT1 strong expression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 3.40 (95% CI 1.39-9.28) and 3.25 (95% CI 1.15-9.16); and for cSCC specific death of 6.17 (95% CI 1.79-21.2) and 6.10 (95% CI 1.45-25.7). Strong LLT1 expression is an independent predictor of nodal metastasis and poor disease-specific survival and it might be helpful for risk stratification of patients with cSCC.

Sentinel lymph node biopsy plus wide local excision vs. wide location excision alone for primary cutaneous melanoma: a systematic review and meta-analysis.

BACKGROUND: Sentinel lymph node biopsy and wide local excision of the primary melanoma (SLNB) is now a standard staging procedure for patients with melanomas 1 mm or more in thickness, but its therapeutic benefit is not clear. OBJECTIVE: To determine whether there is an association between performance of SLNB and patient prognosis. METHODS: Studies assessing the association between performance of SLNB and patient prognosis were pooled from MEDLINE, EMBASE, PubMed, Cochrane Database of Systematic Reviews and Google Scholar. From each study, first author's last name, publication year, origin country, type of study design, characteristics of participants and the Hazard risk (HR) for melanoma specific survival (MSS) with the corresponding 95% confidence interval (95% CI) were collected. Methodological assessment of the studies was evaluated using the Newcastle-Ottawa scale (NOS) and the 'Risk of bias' tool detailed in the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analyses for the global HR were performed. In addition, in order to explore the sources of heterogeneity among the studies, sensitivity analyses are also provided. RESULTS: A total of six studies with 8764 patients who had undergone SLNB and 11054 patients who had undergone wide location excision alone (WLEA) were identified for the analysis. The indicators suggest that the heterogeneity is low: τ2  = 0; H = 1 [1; 1.74]; I2  = 0% [0%; 66.5%]. Evidence for publication bias was not found (Egger's test P = 0.4654). The pooled MSS HR from fixed effects analysis was determined to be 0.88 (95% CI = 0.80-0.96). CONCLUSIONS: Although no significant survival difference was observed in four of the six series, the pooling summary data from all the studies that deal with this issue suggested that SLNB is associated with a significantly better outcome compared with WLEA for localized melanoma.

Acute renal failure caused by imiquimod 5% cream in a renal transplant patient: review of the literature on side effects of imiquimod.

Imiquimod is an immunomodulator of the imidazoquinoline group which possesses antiviral and antitumour activities. Although its mechanism of action has not been entirely elucidated yet, imiquimod 5% cream has been shown to be an efficient, long-lasting and safe therapy for multiple actinic keratoses in non-immunosuppressed patients and in transplant recipients. We report the case of a 44-year-old patient with a third renal transplant who developed an acute tubular necrosis confirmed by renal biopsy after the use of imiquimod 5% cream. The result of a literature search revealed a wide variety of side effects attributable to the use of imiquimod.

Eritema nodoso secundario a fiebre Q / Erythema nodosum secondary to Q fever

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Nevus oligemicus. Aportación de seis casos / Six cases of nevus oligemicus

El hamartoma o nevus oligemicus es una entidad infrecuente, de etiopatogenia poco aclarada, en la que se produce una vasoconstricción selectiva del plexo vascular profundo dérmico con relación al superficial. Estas alteraciones funcionales dan lugar a lesiones fijas, adquiridas y asintomáticas a modo de máculas lívidas, eritematosas, típicamente frías al tacto si se compara con la piel sana adyacente. Comunicamos los casos de 6 varones jóvenes con lesiones en el abdomen y en los flancos, compatibles clínicamente con nevus oligemicus. La medición de la temperatura superficial de la lesión, constatando un descenso de hasta 2,5 °C respecto de la piel sana adyacente, permitió realizar el diagnóstico definitivo. Se describen los estudios complementarios realizados, los diagnósticos diferenciales, los posibles agentes etiológicos responsables y se comentan los casos referidos en la literatura hasta el momento. Consideramos que el nevus oligemicus es una entidad infradiagnosticada y mucho más frecuente de lo referido en la literatura (AU)

Hamartoma or nevus oligemicus is an uncommon lesion that is characterized by selective vasoconstriction of the deep dermal vascular plexus with respect to the superficial one and whose cause has not been clearly established. This selective vasoconstriction gives rise to fixed, acquired, and asymptomatic lesions in the form of livid, erythematous macules that are typically cold to touch compared with surrounding skin. We report the cases of 6 young men with lesions clinically compatible with nevus oligemicus on the abdomen and flanks. Measurement of the surface temperature of the lesion revealed a decrease of up to 2.5 °C with respect to healthy surrounding skin and allowed a definitive diagnosis to be made. We describe the additional studies undertaken, the differential diagnosis, and the possible etiologic agents, and discuss the cases reported in the literature to date. In our opinion, nevus oligemicus is an underdiagnosed lesion that is much more common than has been reported in the literature (AU)

[Six cases of nevus oligemicus]. / Nevus oligemicus. Aportación de seis casos.

Hamartoma or nevus oligemicus is an uncommon lesion that is characterized by selective vasoconstriction of the deep dermal vascular plexus with respect to the superficial one and whose cause has not been clearly established. This selective vasoconstriction gives rise to fixed, acquired, and asymptomatic lesions in the form of livid, erythematous macules that are typically cold to touch compared with surrounding skin. We report the cases of 6 young men with lesions clinically compatible with nevus oligemicus on the abdomen and flanks. Measurement of the surface temperature of the lesion revealed a decrease of up to 2.5 degrees C with respect to healthy surrounding skin and allowed a definitive diagnosis to be made. We describe the additional studies undertaken, the differential diagnosis, and the possible etiologic agents, and discuss the cases reported in the literature to date. In our opinion, nevus oligemicus is an underdiagnosed lesion that is much more common than has been reported in the literature.

Masa tumoral subcutánea en espalda / Subcutaneous tumoral mass on the back

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Multinucleate cell angiohistiocytoma: a new case report.

Multinucleate cell angiohistiocytoma (MCAH) was first described by Smith and Wilson-Jones in 1985. It is an uncommon entity but probably underdiagnosed because of lack of recognition by clinicians and pathologists. We report a 47-year-old man with asymptomatic grouped violaceous papules on the dorsum of the hands for 3 years. The histopathological and immunopathological features of our case revealed characteristics of MCAH similar to the initial description of Smith and Wilson-Jones and other reports.

Accidentes cerebrovasculares de repetición y máculas cutáneas / Recurrent strokes and skin macules

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NEVIL del adulto con hiperplasia papilomatosa multifocal / Adult onset ILVEN with multifocal papillomatous hyperplasia

Los nervios epidérmicos verrugosos son lesiones hamartomatosas que se diferencian esencialmente hacia queratinocitos epidérmicos. Ciertas características clínicas e histopatológicas han permitido la individualización del llamado nevo epidérmico verrugoso inflamatorio lineal (NEVIL). Un varón de 42 años presentaba en la extremidad inferior derecha una dermatosis eritematosa y queratósica que se extendía longitudinalmente siguiendo el trayecto de las líneas de Blaschko. En el seno de la previa dermatosis desarrolló en los últimos años varias lesiones tumorales exofíticas cuyo estudio histológico reveló únicamente una intensa papilomatosis de naturaleza benigna. Describimos el ejemplo de un nevo epidérmico verrugoso inflamatorio lineal que en la edad adulta desarrolló múltiples proliferaciones vegetantes de carácter puramente hiperplásico (AU)

Eritema y descamación en las manos / Hand erythema and scaling

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